UMCU CISUMCU Center for Image Sciences (associated with: EATRIS-NL)

Contact details:

Peter Luijten
Heidelberglaan 100, 3584 CX Utrecht

The Center for Image Sciences is an advanced infrastructure built around high precision magnetic resonance based imaging and therapy guidance, encompassing ultra high field magnetic resonance imaging and spectroscopy for structural, functional and metabolic imaging (currently 7T, to be extended with higher field strengths in the future), MRI guided high intensity focused ultrasound for tissue ablation and localized, targeted drug delivery, MRI guided radiotherapy (brachytherapy, photon & proton therapy), integrated MRI-PET for detection and characterization of localized disease and image guided radio embolization’s.

Ultra high field MRI:
• Available equipment: 7T platform, including multi-transmit capabilities, multi-nuclear capabilities
• Current Research: world leading in first in man research in the area of technology development to study pathophysiology of cerebral small vessel disease (stroke, aneurysms, vascular dementia), ALS, schizophrenia, breast-, prostate-, brain-, upper and lower GI cancer, cardio vascular imaging (atherosclerosis, fibrosis), regenerative imaging (stem cell therapy for cartilage and myocardial muscle repair, valve replacements)
• Future investments: expanding 7T (metabolism), >7T field strengths

MR guided High Intensity Focused Ultrasound (MR-HIFU)
• Available equipment: state of the art MRI (1.5T) guided HIFU
• Current Research: world leading in technology development of MR-HIFU ablations of breast cancer lesions
• Future Investments: infrastructure for local, targeted drug delivery (thermo-sensitive liposomal drug delivery, brain-blood barrier disruption)

MR guided radiotherapy:
• Available external beam equipment: experimental (1), preclinical (1) and clinical (1) integrated MRI – linear accelerator platform for real time, MR guided, adaptive radiotherapy applications
• Available brachytherapy equipment: 1.5T MRI (Ingenia) guided HDR, including MRI compatible robotic applications
• Current Research: the CIS is world leading in MR guided external beam radiation treatments. Future Investments: extending MR guidance into the field of MR guided proton therapy. Design of an experimental MRI guided proton therapy system. Clinical evaluation of such a system within the PMC setting in collaboration with leading industry.

Available equipment: none
• Current Research: with its unique knowledge on MR based, 4D (spatial & temporal resolution) real time conformational studies, MR tissue contrast, combined with new PET tracer capabilities beyond FDG only (e.g. 68Ga-PSMA), the CIS is optimally positioned for the further development and exploration of a fully integrated MRI-PET platform. The uniqueness of the CIS applications will reside in the full incorporation of the MRI-PET based sciences towards therapeutic applications.
• Future Investments: MRI-PET platform for guidance of therapy, based on a 1.5T MRI system (which will discriminate this system from all other currently available MRI-PET systems)

Connection to strategic developments
Health and Food