RTCRadboudumc Technology Centers

Contact details:

Prof.dr. Alain van Gool
PO Box 9101, 6500 HB Nijmegen

The Radboudumc Technology Centers comprises a state-of-the-art integrated infrastructure for technologies and methodologies enabling personalized healthcare. The 18 Technology Centers span the range of molecule to man to population, including platforms for genomics, mass spectrometry, flow cytometry, bioinformatics, stem cells, microscopy, imaging, biobanking, clinical studies, human performance, data analysis, data stewardship and health economics. The Technology Centers intensively work together with each other and with (inter)national public and private partners, providing access to their expertise and capabilities to jointly develop innovations personalized healthcare.

The Radboudumc Technology Centers are organized as a large infrastructure within the Radboudumc that combine molecular and non-invasive technologies with data analyses methodologies. The 18 Technology Centers involve ~250 technology-focused scientists that interact among themselves to generate an integrated infrastructure enabling research and diagnostic applications in personalized healthcare, and who are working with over 2000 public and private users.
Information on the Radboudumc Technology Centers is listed below. More details can be found on the website www.radboudumc.nl/Research/TechnologyCenters/.
- Genomics: exome and genome sequencing services. Details: 9 Next generation sequencing platforms, 15 robotics, 3 Sanger sequencers, high performance data analysis pipeline.
- Mass spectrometry: analytical biomarker (protein, glycan, metabolite) and medication services. 19 MS systems (6 GC-MS, 4 QTOF-MS, 7 QqQ-MS, 2 MALDI-MS).
- Bioinformatics: statistics, bioinformatics, structural genomics.
- Flow cytometry: cell analysis and sorting. 14 flow cytometers/flow sorters (5- to 14-color).
- Stem cells: generation of iPSCells and adult stem cells. Multilaboratory network generating stem cells supporting research purposes.
- Animal studies: centralized animal test facility, executing ~250 animal studies/year.
- Translational neuroscience: observational neurotechnologies to study the basis of cognition, emotion and behavior. Observational infrastructure, touchscreens.
- Microscopy: standard and advanced microscopic analysis of cells, tissues and animals. 50 instruments (incl. fluorescence-, confocal-, electron-, atomic force-, 2-foton- microscopes).
- Imaging: preclinical and clinical imaging. 5 animal imaging modalities (microPET/CT, 2 microMRI, microSPECT/CT, ultrasound and photoacoustic-imaging) and 10 clinical imagers (PET/CT, 5 MRI, SPECT/CT, CT, Ultrasound) in combination with physiological monitoring (EEG, MEG, TMS, TCDs, NIRS).
- Image-guided treatment: field lab environment for image-guided surgery and chemo/radiotherapy, including clinical MRI.
- Investigational products: GMP-certified production facilities producing clinical-grade investigational medicinal products for use in imaging, cellular therapies, malaria treatments, nanomedicine. 3 cleanroom facilities, 1 cyclotron.
- Clinical studies: centralized organization of 600 clinical studies/year.
- Biobank: centralized facility to collect, store and manage biomaterial and associated clinical
data. Freezers, comprehensive data management system, logistics and procedures for delivery.
- Human performance: multiple non-invasive measurements of human performance and function (incl. challenge tests, cerebral blood flow, questionnaires).
- EHR-based research: statistical methodologies for big data mining of Electronic Health Records from GP and hospital care.
- Statistics: expertise infrastructure providing statistical support to research and diagnostic users.
- Data stewardship: comprehensive ICT platform providing infrastructure and support to import, merge, optimize, store, analyze, archive and share data in single scalable workspaces.
- Health economics: expertise to assess the economic viability and value of healthcare innovations at an early stage of development.

Connection to strategic developments
Life Sciences & Health
Health and Food