RTC - ImagingRadboud Imaging Center

Contact details:

Prof.dr. Otto C. Boerman
PO Box 9101, 6500 HB Nijmegen

The Radboud Imaging Center provides the most up-to-date equipment and expertise for imaging research, using the medical imaging modalities: MRI, CT, PET, SPECT, US, FGS and combinations thereof. State of the art equipment is installed for clinical imaging studies (MRI (Siemens 1T, 1.5T, 3T and 7T), CT (Toshiba), PET/CT (Siemens mCT), SPECT/CT (Siemens Symbia), US (Toshiba), MEG imaging (CTF, NIRS), for small animal imaging (MRI (Bruker 7T and Bruker 11.7T), PET/CT (Siemens Inveon), SPECT/CT (Milabs U-SPECT II), US and photoacoustics (Fuji Visualsonics), Multi-photon fluorescence imaging (LaVision Biotec, Coherent) and for advanced microscopy imaging (FRET, FLIM, FCS, TIRF, high content microscopy, confocal microscopy) and superresolution microscopy (STORM and electron microscopy). The Radboud Imaging Center provides the use, the expertise and research infrastructure to develop and apply these imaging modalities for research purposes. In addition, the scientists of the Radboud Imaging Center develop new tools for contrast enhanced MRI imaging (USPIOs, Fluor nanoparticles, a.o.), radiotracers for PET and SPECT imaging, tools for image analysis, advanced US imaging techniques, support for clinical imaging studies, a.o..
The research facilities of the Radboud Imaging Center are organized in eight units, CLIC (Clinical Imaging Center), for clinical imaging studies, DCCN (Donders Center for Cognitive Neuroimaging), MITeC (Medical Innovation Technology Center) for medical imaging on image-guided surgery and intervention, AMI (Automation in Medical Imaging) for automated image analysis, PRIME (Preclinical Imaging Center) for small animal imaging, RTM (Radboud Translational Medicine) a state-of-the-art cyclotron facility for the manufacturing of F-18, C-11 and N-13-labeled radiotracers for preclinical and clinical application, MIC (Microscopic Imaging Center) for microscopic imaging for advanced microscopy imaging and the Radboud-3D lab for advanced 3D imaging applications. The Radboud Imaging Center provides these services for Dutch and international research institutes as well as industry.

The Radboud Imaging Center provides frontline facilities and expertise for noninvasive imaging in patients, animal models and biological samples for biomedical research, as well as IT infrastructure and expertise on handling and processing medical image data. The following facilities are provided:
• CLIC provides noninvasive patient imaging with MRI (1.5 - 7T), CT (up to 320-slice), PET/CT, US, SPECT/CT, and fluorescence imaging. The cyclotron of RTM and GMP facilities for tracer preparation provide a vast spectrum of customized probes for radionuclide imaging. Apart from standard morphological imaging techniques, various novel functional techniques are available with MR, CT, PET and US, some of which are unique for the Netherlands and have been developed in close cooperation with industry.
• DCCN provides morphologic and functional 3 – 7 T MR imaging of the brain, MR morphometry, fMRI, connectivity analysis using resting state fMRI and diffusion weighed imaging.
• MITeC provides intra-operative (hybrid) imaging with MRI and CT as well as other intra-operative imaging techniques such as fluorescence imaging and photoacoustic imaging.
• AMI provides a software platform to support image-based clinical and preclinical studies by providing IT infrastructure for data storage and an effective viewing and quantitative evaluation environment with modules for algorithm development and high-end automation to facilitate evaluation of very large imaging databases.
• RTM provides a 11 MeV cyclotron for production of radionuclide and GMP facilities for production of tracers for PET imaging.
• PRIME is recognized as a node in the EuroBioimaging network and provides advanced equipment for small animal imaging with 11.7 T MRI, 7 T MRI, microPET/CT, microSPECT/CT, high frequency ultrasound (20,40 and 55 MHz), fluorescence imaging, bioluminescence imaging, multi-photon fluorescence imaging and photoacoustic imaging.
• MIC provides facilities for microscopic imaging of biological samples using Advanced Microscopy, such as CLSM, TIRF, FCS, FLIM, SEM, TEM, AFM, multi-photon microscopy, and high-content imaging.
• The Radboud-3D lab provides facilities for Cone Beam CT, 3D stereo-photogrammetry, Intra-oralscanning and 3D printing.

The infrastructure of the Radboud Imaging Center is continuously being updated to incorporate the newest developments in the field. In the near future the Clinical Imaging Center aims to acquire equipment for clinical hyperpolarized MRI. PRIME will acquire equipment for tomographic fluorescence imaging and micro-endoscopic imaging in mice and rats, while the Microscopic Imaging Center will extend its armamentarium with equipment for Multimodal Molecular Imaging. The 7T MRI facilities are shared with the University of Essen; a clinical/research system in Nijmegen is planned for 2018. MIC is currently implementing light-sheet and super-resolution microscopy (STORM, structured illumination microscopy).

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