Generation RGeneration R

Contact details:

Prof. Vincent W.V. Jaddoe
PO Box 2040, 3000 CA Rotterdam

The Generation R Infrastructure is a large population-based prospective cohort study in the City of Rotterdam, the Netherlands among parents and their children followed from fetal life until adulthood. The infrastructure enables studies on genetic, socio-demographic, ethnic, lifestyle related and early environmental factors and pathways leading to reproductive, maternal and childhood health, disease and wellbeing. Data from this infrastructure are available for local, national and international researchers. The data have been used by more than 200 individual researchers from different universities, and resulted in more than 50 PhD theses and 550 peer-reviewed scientific papers during the last 10 years.

The Generation R Infrastructure is a large population-based prospective cohort study in the City of Rotterdam, the Netherlands among young adults, pregnant women and their children from fetal life until adulthood. The infrastructure is coordinated by the Erasmus University Medical Center and Erasmus University Rotterdam, in collaboration with the Municipal Health Service and various caregivers in the City of Rotterdam. The infrastructure has been established in 2002 by recruiting the first cohort (n = 10,000 pregnant women, fathers and their children). The children have been followed form early fetal life onwards. In 2016-2018, a second cohort of 7,000 -10,000 women will be recruited before or early in their pregnancy. The infrastructure enables studies on genetic, socio-demographic, ethnic, lifestyle related and early environmental factors and pathways leading to reproductive, maternal and childhood health, disease and wellbeing. The infrastructure enables studies focused on critical phases and periods of life (reproductive phase, preconception phase, embryonic and fetal life, infancy, childhood, adolescence and young adulthood). Data collection in mothers, fathers and children include questionnaires, detailed physical examinations, behavioral observations, Magnetic Resonance Imaging (MRI) and other imaging techniques, and biological samples. A genome and epigenome-wide association screen is available in the participating children. Data from this infrastructure being used by local, national and international researchers. Since 2006, the data have been used by more than 200 individual researchers from different universities, and resulted in more than 50 PhD theses and 550 peer-reviewed scientific papers. Results forthcoming from the analyses in the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

Connection to strategic developments
Topsectors:
ESFRI:
Health and Food
NWA-Routes: