BPRCBiomedical Primate Research Centre

Contact details:

Ronald Bontrop
Address:Lange Kleiweg 161 2288 GJ Rijswijk

The use of non-human primates (NHP) is still necessary in biomedical research (see also recommendations by the KNAW). In order to refine and reduce the number of NHP in research new techniques need to be implem)nted. The BPRC aims to implement state-of-the art infrastructures for imaging techniques for NHP research and development of ex vivo/in vitro methods (alternatives) , including the possibility to perform a number of these techniques under biocontainment conditions. Currently, the BPRC is already implementing a PET-CT scan (subsidized by the Bill&Melinda Gates Foundation) and new infrastructure around these techniques needs further development.

Disease causes misery and large numbers of deaths in human populations worldwide. For many common deadly diseases there is still a desperate need for effective medicines. BPRC is a scientific research institute that exists to perform vital research that contributes to the identification and development of these new medicines and therapies. BPRC is committed to using non-human primates for this critical research, but only where there are no suitable alternatives. Research is also required to identify and develop alternatives to the use of non-human primates. BPRC has an active and expanding program to develop alternatives following the principles of reduction, refinement and replacement. The BPRC provides unique expertise and facilities. The institute has its own closed breeding colony of non-human primates. All animals have a thoroughly characterized microbiological status and they are MHC-typed. The BPRC colonies belong to the best characterized NHP colonies in the world and provide unique opportunities for biomedical research in those cases where NHP needs to be involved. BPRC has also a biobank with unique material that can be provided to the research community. BPRC is also a central facility in the Netherlands to study NHP behavior. The animal welfare standards of the BPRC belong to the highest in the world. The BPRC was the first primate center in Europe to receive AAALAC accreditation. The combination of high-level research groups and unique NHP facilities make the BPRC a unique infrastructure that can provide specialized expertise and NHP models to the research community. This includes also the development of alternatives to refine, reduce or ultimately replace NHP models. The BPRC is acknowledged as Central Facility for the testing of new TB vaccination strategies by the Bill & Melinda gates Foundation. The BPRC received a large investment grant from the BMGF to include a PET-CT Scan under biocontainment conditions, and currently the infrastructure is adapted to include the PET-CT Scan. This will allow further possibilities for research in the areas of expertise at the BPRC. Areas of expertise include behavioural research, infectious diseases, neurodegenerative diseases and auto-immune diseases. The BPRC can offer its expertise and facilities for (joined) research using NHP models.

Connection to strategic developments
Health and Food