BDCBiomarker Development Center

Contact details:

Rainer Bischoff
Antonius Deusinglaan 1, 9713 AV Groningen
+31 6 52000506

The Biomarker Development Center (BDC) is an initiative of the University of Groningen (RUG), the University Medical Center Groningen (UMCG), the Erasmus Medical Center Rotterdam (EMC) and the Radboud University Medical Center (RUMC). The BDC focuses on protein and metabolite biomarker verification, validation and qualification in a multi-centric setting involving technology-oriented and clinical centers. The current major disease areas are Chronic Obstructive Pulmonary Disease (COPD), Diabetes Type II and Alzheimer’s Disease.

The BDC is equipped with state-of-the-art instrumentation worth ca. 20 million euro comprising high-end mass spectrometers, a bioinformatics infrastructure and close links to clinical research groups and biobanks (e.g. via DTL, BBMRI, EATRIS, ELIXIR). The BDC performs targeted quantitative bioanalysis of proteins, peptides and metabolites, the analysis of complex samples (e.g. plasma, serum) and has cutting-edge know-how in processing and statistically analyzing highly complex, multi-variate datasets for comparative proteomics and metabolomics. The BDC is closely linked to local and national genomics facilities integrating Next Generation Sequencing data in a proteo- or metabolo-genomics (Systems Medicine) approach. In close collaboration with clinicians and patient stakeholder organisations, the BDC develops novel instrumental and bioinformatics approaches to advance the biomarker discovery pipeline all the way to clinical application.
The BDC is staffed with 50 people (ca. 15 full-time staff members) of which 10 technicians assuring both routine and research activities in the laboratory. We interact closely with (bio)informatics groups (e.g. TNO) for data processing and statistical data analysis combined with 'in-house' development of algorithms and software.

Connection to strategic developments
Life Sciences & Health
Health and Food